Meat Lovers Pizza Casserole: A Cheesy, Meaty Crowd-Pleaser the Whole Family Will Love

When you’re craving something warm, cheesy, and completely satisfying, there’s no competition—pizza and casseroles are two of the ultimate comfort foods. So why not combine the two? That’s exactly what this Meat Lovers Pizza Casserole does. It’s a baked pasta dish that brings together everything you love about pizza gooey cheese, savory sauce, and loads of meaty toppings layered into one easy, hearty casserole.

This dish is perfect for busy weeknights, game day gatherings, or anytime you’re feeding a hungry crowd. It’s packed with all the best pizza meats like sausage, ground beef, and pepperoni, but instead of a crust, you get tender rotini pasta baked into the mix. Each forkful is cheesy, saucy, and full of bold pizza flavor.

If your family loves pizza night, this casserole is about to become a new favorite in your dinner rotation. It’s easy to make, comforting to eat, and guaranteed to leave everyone asking for seconds.

this Recipe

What Is Meat Lovers Pizza Casserole?

Meat Lovers Pizza Casserole is a baked pasta dish that combines the flavors of a classic meat lovers pizza with the comfort of a cheesy pasta bake. It’s loaded with rotini (or your favorite pasta), pizza sauce, mozzarella cheese, and layers of hearty meats like ground beef, sausage, and pepperoni.

Instead of fussing with pizza dough, this casserole lets you enjoy all the toppings baked into a single dish. It’s everything you love about pizza, with the ease of a one-pan pasta dinner.

Why You’ll Love This Recipe

• All the meat lovers’ favorites in one dish – Sausage, beef, pepperoni, and cheese!
• Simple ingredients – No complicated steps or specialty items needed.
• Easy to prepare ahead – Assemble it early and bake it when ready.
• Perfect for feeding a crowd – It makes generous portions for hungry guests.
• Kid-friendly and family-approved – Pizza flavors are always a hit at the table.
• Freezer-friendly – Save leftovers for a quick, delicious meal later.

What Does Meat Lovers Pizza Casserole Taste Like?

Each bite of this casserole is packed with savory, cheesy goodness. The pasta soaks up the pizza sauce, while the combination of Italian sausage and ground beef adds richness and depth. The pepperoni gives it that classic pizza flavor, and the gooey mozzarella cheese melts into every layer.

It’s meaty, cheesy, and just the right amount of saucy. Think of it as a mashup of baked ziti, lasagna, and your favorite pizza all rolled into one comforting meal. It’s indulgent, satisfying, and perfect for those nights when you need something cozy and filling.

Benefits of Making Meat Lovers Pizza Casserole

• One-pan convenience – Everything bakes together in a single casserole dish.
• Customizable – Add your favorite pizza toppings or change up the meats.
• Hearty and filling – Packed with protein and carbs to keep everyone satisfied.
• Crowd-pleasing comfort food – A guaranteed hit at potlucks, parties, or family dinners.
• Freezes well – Make a double batch and freeze one for later.

Ingredients for Meat Lovers Pizza Casserole

Here’s what you’ll need to make this meaty, cheesy casserole:

• 12 oz rotini pasta (or any short pasta like penne or ziti)
• 1/2 lb ground beef
• 1/2 lb Italian sausage, casing removed
• 2 cups marinara or pizza sauce
• 2 cups shredded mozzarella cheese
• 1/2 cup sliced pepperoni
• 1/4 cup grated Parmesan cheese
• 1/2 tsp garlic powder
• 1/2 tsp onion powder
• 1 tsp Italian seasoning
• Salt and black pepper, to taste
• Optional garnish: chopped parsley or dried oregano

Tools You’ll Need

• Large skillet
• 9×13-inch casserole dish
• Large pot for boiling pasta
• Mixing bowls
• Wooden spoon or spatula

Ingredient Swaps & Additions

• Add veggies – Toss in mushrooms, bell peppers, or onions for extra flavor.
• Make it spicy – Use spicy Italian sausage or add crushed red pepper flakes.
• Try different cheeses – Mix mozzarella with provolone or cheddar for variety.
• Use turkey sausage or ground turkey – Lighten it up without sacrificing flavor.
• Switch the pasta – Penne, fusilli, or elbow macaroni all work well.

How to Make Meat Lovers Pizza Casserole

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Cook the rotini until al dente according to package directions. Drain and set aside.

Step 2: Brown the Meats

In a large skillet over medium heat, cook the ground beef and Italian sausage until fully browned. Break the meat into crumbles as it cooks. Drain any excess fat from the skillet.

Step 3: Season the Meat

Stir in the garlic powder, onion powder, Italian seasoning, salt, and pepper. Mix well to combine.

Step 4: Assemble the Casserole

In a large mixing bowl, combine the cooked pasta, meat mixture, and marinara or pizza sauce. Stir until the pasta is fully coated.

Pour half of the pasta mixture into a greased 9×13-inch casserole dish. Sprinkle 1 cup of mozzarella cheese on top, then add half of the pepperoni slices.

Layer the remaining pasta mixture on top. Finish by adding the rest of the mozzarella cheese, the Parmesan cheese, and the remaining pepperoni slices.

Step 5: Bake

Preheat your oven to 375°F (190°C). Bake the casserole uncovered for 20-25 minutes, or until the cheese is melted, bubbly, and golden.

Step 6: Serve

Remove from the oven and let the casserole rest for 5 minutes before serving. Garnish with chopped parsley or dried oregano if desired.

What to Serve with Meat Lovers Pizza Casserole

This casserole is a complete meal on its own, but you can round out your table with:

• Garlic bread or breadsticks
• A simple side salad with Italian dressing
• Roasted vegetables or steamed broccoli
• Pickles or pepperoncini for a tangy side
• Iced tea, lemonade, or your favorite soda

Tips for Success

• Use quality cheese – Freshly shredded mozzarella melts better than pre-bagged.
• Don’t overcook the pasta – Al dente is best since it will bake in the oven.
• Drain the meat well – Prevents the casserole from getting greasy.
• Make it ahead – Assemble the casserole up to a day in advance and bake when ready.
• Freeze for later – Assemble and freeze before baking for an easy future meal.

Storage Instructions

• Fridge: Store leftovers in an airtight container for up to 4 days.
• Freezer: Freeze the casserole (baked or unbaked) for up to 3 months.
• Reheat: Warm in the oven at 350°F until heated through, or microwave individual servings.

Frequently Asked Questions

Can I use pizza sauce instead of marinara?

Yes! Pizza sauce is perfect for this recipe because it adds that classic pizza flavor. Marinara works too if that’s what you have on hand.

Can I make this casserole without sausage?

Absolutely. You can use all ground beef, ground turkey, or even plant-based crumbles if you prefer.

Is this casserole spicy?

It’s not spicy by default, but you can make it spicy by using hot Italian sausage or adding red pepper flakes.

Can I freeze Meat Lovers Pizza Casserole?

Yes! Assemble it ahead and freeze before baking, or freeze leftovers after baking. Just cover tightly with foil and freeze for up to 3 months.

Conclusion

If you’re looking for a family-friendly meal that’s easy to prepare, ultra-comforting, and guaranteed to satisfy, this Meat Lovers Pizza Casserole is the recipe for you. It’s cheesy, meaty, and full of the pizza flavors everyone loves—without the need to roll out dough or order takeout.

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July 16, 2025 by Melissa