Quick & Easy Chicken Alfredo Stuffing Casserole – Creamy, Cheesy, and Perfect for Weeknights

There’s something special about a meal that feels homemade and comforting but comes together effortlessly. This Quick & Easy Chicken Alfredo Stuffing Casserole is exactly that kind of recipe. It’s rich, creamy, and packed with tender chicken, savory stuffing, and melted cheese in every bite. Made with just a few pantry staples, this dish brings together all the best parts of a family dinner in one bubbling casserole dish.

Imagine layers of creamy Alfredo sauce, juicy shredded chicken, and crispy, golden-brown stuffing on top. It’s the kind of meal that makes your kitchen smell incredible and brings everyone to the table fast. Whether you’re looking for a weeknight dinner idea or a cozy holiday-inspired casserole, this recipe delivers creamy comfort with minimal effort.

What Is Chicken Alfredo Stuffing Casserole

Chicken Alfredo Stuffing Casserole combines two comfort food favorites into one: creamy chicken Alfredo and classic savory stuffing. The chicken and Alfredo sauce create a rich base, while the stuffing bakes on top until golden and slightly crisp. The result is a dish that’s creamy underneath, crunchy on top, and completely satisfying.

It’s a one-dish meal that feels homemade but doesn’t require a lot of prep. You can use store-bought rotisserie chicken, boxed stuffing mix, and jarred Alfredo sauce to make things even easier. It’s ideal for busy weeknights, potlucks, or when you just want something hearty without spending hours in the kitchen.

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Why You’ll Love This Recipe

This casserole takes less than 40 minutes from start to finish, uses simple ingredients, and tastes like something straight out of a restaurant. It’s creamy, cheesy, and full of savory flavor. The stuffing topping adds the perfect amount of texture, giving you a crispy bite with every forkful.

You’ll love that it’s completely flexible. Use turkey instead of chicken for a post-holiday dinner, or swap in broccoli for extra veggies. It’s an all-in-one dish that saves you time without sacrificing flavor.

Most importantly, this recipe is family-approved. Even picky eaters love the combination of creamy Alfredo and toasty stuffing.

How Does It Taste?

Each bite of this casserole is the perfect balance of creamy, cheesy, and crunchy. The Alfredo sauce creates a silky texture that coats the tender chicken, while the melted cheese adds richness and flavor. The stuffing topping bakes to golden perfection, adding a buttery crunch that contrasts beautifully with the creamy filling.

It’s comfort food at its best—savory, warm, and satisfying. The flavor is reminiscent of a chicken pot pie, but creamier and cheesier with that unmistakable Alfredo twist.

Health & Ingredient Benefits

While this casserole feels indulgent, it’s made with wholesome, protein-rich ingredients. Chicken provides lean protein, and using light Alfredo sauce or Greek yogurt in the mix can make it lighter while keeping it creamy. You can also add vegetables like spinach, broccoli, or peas for extra nutrients and color.

Stuffing mix adds heartiness and flavor, while cheese provides calcium and a melty, comforting finish. It’s an easy way to use up leftover chicken or turkey in a delicious, crowd-pleasing meal.

Ingredients You’ll Need

For the Casserole Base:

• 3 cups cooked chicken, shredded or chopped
• 2 cups Alfredo sauce (store-bought or homemade)
• 1 cup shredded mozzarella cheese
• ½ cup shredded Parmesan cheese
• ½ teaspoon garlic powder
• ½ teaspoon onion powder
• Salt and pepper to taste

For the Stuffing Topping:

• 1 (6-ounce) box stuffing mix
• 1 ½ cups hot water (or as directed on package)
• 3 tablespoons butter

Optional Add-Ins:

• 1 cup steamed broccoli or spinach
• ½ cup cooked bacon bits
• Fresh parsley for garnish

Tools You’ll Need

• 9×13-inch baking dish
• Large mixing bowl
• Spoon or spatula
• Saucepan or microwave-safe bowl (for stuffing)
• Measuring cups and spoons

Optional Substitutions & Additions

• Protein: Use leftover turkey, ham, or rotisserie chicken.
• Vegetarian: Replace chicken with sautéed mushrooms, spinach, and cauliflower.
• Cheese: Add Swiss or provolone for more depth.
• Lighter version: Use light Alfredo sauce or half-and-half instead of heavy cream.
• Extra crunch: Sprinkle breadcrumbs or crushed crackers on top of the stuffing.

How to Make

1. Preheat the oven: Set your oven to 375°F (190°C) and lightly grease your baking dish.
2. Make the stuffing: In a bowl, combine the stuffing mix with hot water and butter according to package directions. Let it sit to absorb the liquid.
3. Prepare the chicken mixture: In a large mixing bowl, combine shredded chicken, Alfredo sauce, mozzarella, Parmesan, garlic powder, onion powder, salt, and pepper. Mix until well coated.
4. Assemble the casserole: Spread the creamy chicken mixture evenly into your prepared baking dish. Spoon the prepared stuffing evenly on top.
5. Bake: Bake uncovered for 25–30 minutes until the top is golden and crispy, and the sauce is bubbly around the edges.
6. Garnish and serve: Sprinkle with fresh parsley and serve warm.

What to Serve With

This casserole pairs perfectly with a side salad, roasted vegetables, or garlic bread. You can also serve it with cranberry sauce or roasted green beans for a meal that feels like a cozy holiday dinner. For dessert, something simple like apple crisp or brownies complements it beautifully.

It’s hearty enough to be a complete meal on its own, but versatile enough to serve as a side dish at potlucks or family gatherings.

Why It’s Perfect for Busy Nights and Holidays

The Chicken Alfredo Stuffing Casserole is ideal for busy weeknights or as an easy make-ahead dish for the holidays. It’s quick to prep, uses minimal ingredients, and bakes up beautifully in one pan. It’s also a great way to use leftover chicken or turkey after Thanksgiving.

Because it’s rich and filling, it feeds a crowd easily. Plus, the flavors are comforting and familiar, making it a favorite for family dinners or gatherings.

Tips for Success

• Use rotisserie chicken for convenience and flavor.
• Do not overbake, or the stuffing can dry out. Bake until golden and bubbly.
• For a creamier base, add an extra half cup of Alfredo sauce.
• Add vegetables directly to the chicken mixture for extra nutrition.
• Broil for 1–2 minutes at the end for a crispier top.

Common Mistakes to Avoid

• Skipping seasoning: Always taste the chicken mixture before baking. Salt and pepper make a big difference.
• Too much liquid in the stuffing: Make sure it’s moist but not soggy before spreading on top.
• Using uncooked chicken: Always use pre-cooked chicken since the casserole only needs to bake for about 30 minutes.
• Overbaking: It can dry out the sauce and stuffing. Bake just until golden.

How to Store & Reheat

Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven at 350°F for 15 minutes or in the microwave for 1–2 minutes per serving. Add a splash of milk or Alfredo sauce before reheating to keep it moist.

You can also freeze it. Wrap the cooled casserole tightly in foil and freeze for up to 2 months. Thaw overnight in the refrigerator and reheat before serving.

Frequently Asked Questions

Can I make this ahead of time?
Yes. Assemble the casserole, cover tightly, and refrigerate for up to 24 hours before baking. Bake as directed when ready to serve.

Can I use homemade Alfredo sauce?
Absolutely. Homemade sauce adds even more flavor. You’ll need about 2 cups of sauce for this recipe.

Can I use turkey instead of chicken?
Yes. It’s a great way to use up Thanksgiving or holiday leftovers.

Can I add vegetables?
Yes. Broccoli, spinach, peas, or mushrooms all work well in this dish.

Nutritional Info (approximate per serving)

Calories: 420 | Fat: 23g | Carbohydrates: 24g | Protein: 28g | Fiber: 1g | Sodium: 820mg

Conclusion

This Quick & Easy Chicken Alfredo Stuffing Casserole is the ultimate comfort food. Creamy, cheesy, and topped with golden stuffing, it’s a hearty and satisfying dish that’s perfect for any night of the week. It brings together the creamy richness of Alfredo with the buttery crunch of stuffing for a meal everyone will love.

It’s a true one-pan wonder that’s simple enough for busy nights but special enough for family gatherings or holiday meals. From the first creamy bite to the last crunchy topping, this casserole will quickly become a favorite in your dinner rotation.

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October 31, 2025 by Melissa